The ATP1B2 Polyclonal Antibody (CAB16768) is a valuable tool for researchers studying the ATP1B2 protein, a key component of the Na+/K+ ATPase enzyme. This antibody, derived from rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to ATP1B2, this antibody enables precise detection and analysis of the protein in various cell types, making it ideal for investigations in cell biology and physiology.ATP1B2 is essential for maintaining cellular ion balance and membrane potential, playing a crucial role in numerous physiological processes such as muscle contraction, nerve impulse transmission, and kidney function.
Dysregulation of ATP1B2 function has been implicated in various diseases including hypertension, heart failure, and neurological disorders. Research on ATP1B2 is therefore vital for understanding the pathogenesis of these conditions and developing targeted therapies. In summary, the ATP1B2 Polyclonal Antibody offers researchers a reliable tool for exploring the function and regulation of ATP1B2 in health and disease, providing valuable insights into the molecular mechanisms underlying various physiological processes.
Product Name:
ATP1B2 Rabbit Polyclonal Antibody
SKU:
CAB16768
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 68-290 of human ATP1B2 (NP_001669.3).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
33kDa
Observed MW:
Refer to figures
The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
482
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat brain using ATP1B2 Rabbit pAb (CAB16768) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
