The ATAD5 Polyclonal Antibody (PAC019327) is a valuable tool for research involving the ATAD5 protein, which is involved in DNA repair and maintenance of genomic stability. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in various applications such as Western blotting.ATAD5 is a key player in the DNA damage response pathway, playing a critical role in the recognition and repair of damaged DNA. Dysregulation of ATAD5 has been implicated in various diseases, including cancer, where genomic instability is a hallmark.
By targeting ATAD5, researchers can explore its role in DNA repair mechanisms and potentially develop novel therapeutic strategies for cancer treatment.The ATAD5 Polyclonal Antibody is an essential tool for studying the function of ATAD5 in DNA repair processes and its potential as a target for cancer therapy. Its versatility and specificity make it an excellent choice for researchers in the fields of molecular biology and cancer research.
Antibody Name:
ATAD5 Antibody (PACO19327)
Antibody SKU:
PACO19327
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ATAD5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A431 cells, Primary antibody: PACO19327(ATAD5 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds.
Background:
ATAD5 (ATPase family, AAA domain containing 5), also known as chromosome fragility-associated gene 1 protein, FRAG1 or ELG1, is a 1,844 amino acid, nuclear protein that is involved in the DNA damage response and belongs to the AAA ATPase family. Existing as two alternatively spliced isoforms, ATAD5 interacts with Rad9 in growing cells where it assists in interactions between Rad9 and Bcl-2.
Synonyms:
ATPase family, AAA domain containing 5
UniProt Protein Function:
ATAD5: Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17q11.2Cellular Component: nucleusMolecular Function: ATP bindingBiological Process: response to DNA damage stimulus
