The ASIC3 Polyclonal Antibody (CAB10268) is a vital tool for researchers studying ASIC3, a member of the acid-sensing ion channel family involved in sensory perception and pain modulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for Western blot analysis. By binding to the ASIC3 protein, researchers can accurately detect and analyze its expression in different cell types, providing valuable insights into its role in nociception and potential therapeutic targets for pain management.
ASIC3 is known for its involvement in mediating acid-induced pain and inflammatory responses, making it a promising target for developing novel analgesic drugs. By understanding the mechanisms underlying ASIC3 function, researchers can unravel its contribution to chronic pain conditions, such as neuropathic pain and migraine. The ASIC3 Polyclonal Antibody offers a reliable tool for investigating ASIC3 function and its therapeutic implications in pain research and drug discovery efforts.
Product Name:
ASIC3 Rabbit Polyclonal Antibody
SKU:
CAB10268
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 62-320 of human ASIC3 (NP_064717.1).
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, two hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is an acid sensor and may play an important role in the detection of lasting pH changes. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 2 has been observed as proton-gated channels sensitive to gadolinium. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
9311
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ASIC3 antibody (CAB10268) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
