The ASB8 Polyclonal Antibody (PAC040590) is a research tool designed for studying ASB8, a protein involved in ubiquitin-mediated proteolysis. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in various applications, including Western blotting. By targeting the ASB8 protein, researchers can analyze its expression and function in different cell types, making it a valuable tool for investigations in molecular biology and disease mechanisms.ASB8 plays a critical role in the regulation of protein degradation through the ubiquitin-proteasome system, making it a key player in cellular homeostasis and signaling pathways.
Dysregulation of ASB8 has been associated with various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. By elucidating the molecular mechanisms of ASB8, researchers can gain insights into disease pathogenesis and develop novel approaches for intervention and treatment strategies.
Western blot. All lanes: ASB8 antibody at 1µg/ml + Human placenta tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.
Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO40590 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO40590 at dilution of 1:100.
Background:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms:
Ankyrin repeat and SOCS box protein 8 (ASB-8), ASB8
UniProt Protein Function:
ASB8: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.Chromosomal Location of Human Ortholog: 12q13.11Cellular Component: cytoplasmBiological Process: protein ubiquitination
