The ASB10 Polyclonal Antibody (PAC039226) is a vital tool for researchers studying ASB10, a critical protein involved in cellular processes and regulation. This antibody, produced in rabbits, exhibits strong reactivity with human samples, making it ideal for Western blot applications. By binding specifically to ASB10, researchers can accurately detect and analyze this protein in a variety of cell types, facilitating investigations in areas such as cell biology, signal transduction, and disease pathology.ASB10 is known for its role as a substrate recognition component of an E3 ubiquitin-protein ligase complex, playing a key part in protein degradation pathways and cellular homeostasis.
Its involvement in regulating protein turnover and stability makes it a target of interest in studies related to cellular function, disease mechanisms, and therapeutic development. By gaining insight into the functions of ASB10, researchers may uncover new strategies for treating conditions such as neurodegenerative diseases, cancer, and metabolic disorders.
Immunohistochemistry of paraffin-embedded human liver cancer using PACO39226 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO39226 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human lung tissue using PACO39226 at dilution of 1:100.
Background:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms:
Ankyrin repeat and SOCS box protein 10 (ASB-10), ASB10
UniProt Protein Function:
ASB10: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 7q36.1Cellular Component: cytoplasm; nucleusDisease: Glaucoma 1, Open Angle, F
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. The SOCS box serves to couple suppressor of cytokine signaling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Dec 2008]
