The ARSD Polyclonal Antibody (PAC023386) is a valuable tool for researchers studying the ARSD protein, an enzyme involved in the detoxification of potentially harmful compounds in the body. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ARSD protein, it enables accurate detection and analysis in a variety of cell types, making it well-suited for investigations in toxicology, drug metabolism, and liver function.ARSD, or Arylsulfatase D, plays a crucial role in the breakdown of sulfate esters, which are important for the metabolism of various drugs, hormones, and other molecules in the body.
Dysregulation of ARSD activity has been implicated in conditions such as drug toxicity, developmental disorders, and metabolic diseases. Understanding the function of ARSD is essential for developing strategies to modulate its activity and potentially treat associated disorders.Overall, the ARSD Polyclonal Antibody is a valuable asset for researchers interested in studying the role of ARSD in health and disease, providing reliable and specific detection in experimental settings.
Synthesized peptide derived from internal of human ARSD.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ARSD antibody.
Immunofluorescence analysis of MCF-7 cells, using ARSD antibody.
Background:
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y.
Synonyms:
Arylsulfatase D; EC 3.1.6.-; ASD;
UniProt Protein Function:
ARSD: is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]
UniProt Protein Details:
Protein type:EC 3.1.6.-; Hydrolase
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: endoplasmic reticulum lumen
Molecular Function:arylsulfatase activity
Biological Process: glycosphingolipid metabolic process; post-translational protein modification
NCBI Summary:
The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for the correct composition of bone and cartilage matrix. The encoded protein is postranslationally glycosylated and localized to the lysosome. This gene is located within a cluster of similar arylsulfatase genes on chromosome X. A related pseudogene has been identified in the pseudoautosomal region of chromosome Y. [provided by RefSeq, Jul 2011]
