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ARPC4 Antibody (PACO56318)

SKU:
PACO56318
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ARPC4 Antibody PACO56318
  • ARPC4 Antibody PACO56318
€339
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Description

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ARPC4 Antibody (PACO56318)

The ARPC4 Polyclonal Antibody (PAC056318) is a valuable tool for researchers studying the ARPC4 protein, a key component of the actin-related protein 2/3 complex involved in cell motility and cytoskeletal rearrangement. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.ARPC4 is essential for the regulation of actin polymerization and cell migration, making it a crucial target for studies in cell biology and cancer research.

By binding to ARPC4, this antibody enables precise detection and analysis of the protein in various cell types, providing valuable insights into its function and potential roles in disease development.With its high reactivity and specificity, the ARPC4 Polyclonal Antibody is a powerful tool for researchers aiming to unravel the molecular mechanisms underlying cell movement and invasion, and its implications in pathological conditions such as cancer metastasis.

Antibody Name:ARPC4 Antibody (PACO56318)
Antibody SKU:PACO56318
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:200-1:500, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Actin-related protein 2/3 complex subunit 4 protein (2-168AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageIHC image of PACO56318 diluted at 1:300 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Product ImageImmunofluorescence staining of Hela cells with PACO56318 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
Synonyms:Actin-related protein 2/3 complex subunit 4 (Arp2/3 complex 20 kDa subunit) (p20-ARC), ARPC4, ARC20
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010]
UniProt Code:P59998
NCBI GenInfo Identifier:311771642
NCBI Gene ID:10093
NCBI Accession:NM_005718.4
UniProt Secondary Accession:P59998
UniProt Related Accession:P59998
Molecular Weight:
NCBI Full Name:Homo sapiens actin related protein 2/3 complex subunit 4 (ARPC4), transcript variant 1, mRNA
NCBI Synonym Full Names:actin related protein 2/3 complex subunit 4
NCBI Official Symbol:ARPC4  
NCBI Official Synonym Symbols:ARC20; P20-ARC  
NCBI Protein Information:actin-related protein 2/3 complex subunit 4
UniProt Protein Name:Actin-related protein 2/3 complex subunit 4
UniProt Synonym Protein Names:Arp2/3 complex 20 kDa subunit
Protein Family:Actin-related protein 2/3 complex
UniProt Gene Name:ARPC4  
UniProt Entry Name:ARPC4_HUMAN
Antibodies
ARPC4 Antibody (PACO07862)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

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