Anti-ARHGEF10 Antibody (PACO15513)

Antibody Name:	ARHGEF10 Antibody (PACO15513)
Antibody SKU:	PACO15513
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human ARHGEF10

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15513(ARHGEF10 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15513(ARHGEF10 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).

Background:

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. ARHGEF10 (rho guanine nucleotide exchange factor 10), also known as GEF10 or KIAA0294, is a 1,369 amino acid, protein that contains one DBL-homology domain and is thought to play a role in myelination of peripheral nerves, specifically during development. ARHGEF10 is expressed as four alternatively spliced isoforms that are present at low levels in ovary, lung, testis and kidney, with considerably higher expression in the central and peripheral nervous systems.

Synonyms:

Rho guanine nucleotide exchange factor (GEF) 10

UniProt Protein Function:	ARHGEF10: May play a role in developmental myelination of peripheral nerves. Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV). Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. 5 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs, Rac/Rho; GEFsChromosomal Location of Human Ortholog: 8p23Cellular Component: centrosome; cytosolMolecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; kinesin bindingBiological Process: positive regulation of stress fiber formation; centrosome duplication; myelination in the peripheral nervous systemDisease: Slowed Nerve Conduction Velocity, Autosomal Dominant
UniProt Protein Details:
NCBI Summary:	Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]
UniProt Code:	O15013
NCBI GenInfo Identifier:	62548864
NCBI Gene ID:	9639
NCBI Accession:	NP_055444.2
UniProt Secondary Accession:	O15013,O14665, Q2KHR8, Q68D55, Q8IWD9, Q8IY77
UniProt Related Accession:	O15013
Molecular Weight:	151,612 Da
NCBI Full Name:	rho guanine nucleotide exchange factor 10
NCBI Synonym Full Names:	Rho guanine nucleotide exchange factor (GEF) 10
NCBI Official Symbol:	ARHGEF10
NCBI Official Synonym Symbols:	GEF10
NCBI Protein Information:	rho guanine nucleotide exchange factor 10
UniProt Protein Name:	Rho guanine nucleotide exchange factor 10
UniProt Synonym Protein Names:
Protein Family:	Rho guanine nucleotide exchange factor
UniProt Gene Name:	ARHGEF10
UniProt Entry Name:	ARHGA_HUMAN

Antibodies

ARHGEF10 Antibody (PACO00420)

ARHGEF10 Antibody (PACO07831)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)