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ARHGAP35 Antibody (PACO03988)

SKU:
PACO03988
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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ARHGAP35 Antibody (PACO03988)

The ARHGAP35 Polyclonal Antibody (PACO03988) is a valuable tool for researchers studying the ARHGAP35 protein, which plays an important role in cellular signaling pathways and cytoskeletal regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ARHGAP35, also known as Rho GTPase-activating protein 35, is involved in the regulation of Rho family GTPases, which are key regulators of cell migration, proliferation, and differentiation. By binding to ARHGAP35, this antibody enables detection and analysis of the protein in various cell types, providing valuable insights into its functions and potential implications in disease.

Research into ARHGAP35 is particularly relevant in the fields of cell biology, cancer research, and neurobiology, as dysregulation of Rho GTPase signaling is associated with various diseases, including cancer metastasis and neurological disorders. By studying ARHGAP35 and its interactions, researchers can gain a better understanding of these cellular processes and potentially identify new targets for therapeutic intervention.

Antibody Name:ARHGAP35 Antibody
Antibody SKU:PACO03988
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human GRF-1 around the non-phosphorylation site of Y1105.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ARHGAP35; GRF1; GRLF1; KIAA1722; Rho GTPase-activating protein 35; Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A; p190-A
UniProt Protein Function:GRF-1: the human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTP-ase activating protein (GAP). May also act as a tumor suppressor. Two splice variant isoforms have been described. Protein type: Motility/polarity/chemotaxis; GAPs, Rac/Rho; Transcription factor; GAPs; Tumor suppressorChromosomal Location of Human Ortholog: 19q13.3Cellular Component: cytosol; nucleus; actin cytoskeletonMolecular Function: GTP binding; DNA binding; transcription corepressor activityBiological Process: regulation of cell shape; axon guidance; regulation of small GTPase mediated signal transduction; camera-type eye development; negative regulation of Rho protein signal transduction; transcription, DNA-dependent; small GTPase mediated signal transduction; neural tube closure; forebrain development; negative regulation of vascular permeability; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
UniProt Code:Q9NRY4
NCBI GenInfo Identifier:150417981
NCBI Gene ID:2909
NCBI Accession:NP_004482.4
UniProt Secondary Accession:Q9NRY4,Q14452, Q9C0E1, A7E2A4
UniProt Related Accession:Q9NRY4
Molecular Weight:155kDa
NCBI Full Name:rho GTPase-activating protein 35
NCBI Synonym Full Names:Rho GTPase activating protein 35
NCBI Official Symbol:ARHGAP35  
NCBI Official Synonym Symbols:GRF-1; GRLF1; P190A; P190-A; p190RhoGAP; p190ARhoGAP  
NCBI Protein Information:rho GTPase-activating protein 35; rho GAP p190A; glucocorticoid receptor repression factor 1; glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1
UniProt Protein Name:Rho GTPase-activating protein 35
UniProt Synonym Protein Names:Glucocorticoid receptor DNA-binding factor 1; Glucocorticoid receptor repression factor 1; GRF-1; Rho GAP p190A
Protein Family:
UniProt Gene Name:ARHGAP35  
UniProt Entry Name:RHG35_HUMAN

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