The ARHGAP31 Polyclonal Antibody (PAC004823) is a valuable tool for researchers studying ARHGAP31, a protein involved in cell signaling and regulation of the cytoskeleton. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By binding to the ARHGAP31 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential component for studies in cell biology and cancer research.ARHGAP31, also known as Rho GTPase-activating protein 31, plays a crucial role in modulating the activity of Rho family GTPases, key regulators of cell migration, proliferation, and cytoskeletal dynamics.
Dysregulation of ARHGAP31 has been implicated in various diseases, including cancer and neurological disorders, highlighting its importance as a therapeutic target. Investigating the function of ARHGAP31 with the help of this antibody can provide insights into the mechanisms underlying these pathologies and aid in the development of targeted treatments.
Antibody Name:
ARHGAP31 Antibody
Antibody SKU:
PACO04823
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from human CdGAP around the non-phosphorylation site of T789.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ARHGAP31; CDGAP; KIAA1204; Rho GTPase-activating protein 31; Cdc42 GTPase-activating protein
UniProt Protein Function:
CdGAP: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 3q13.33Cellular Component: cytosol; lamellipodiumMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transductionDisease: Adams-oliver Syndrome 1
UniProt Protein Details:
NCBI Summary:
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]
