The ARHGAP26 Polyclonal Antibody (PACO43679) is designed for research involving ARHGAP26, a protein known for its role in regulating cell adhesion, migration, and invasion. The antibody, raised in rabbits, is highly specific to human samples and is validated for use in various applications, including Western blot and immunofluorescence.ARHGAP26, also known as Rho GTPase-activating protein 26, is a key player in controlling the activity of Rho GTPases, which are crucial for the dynamics of the actin cytoskeleton and cell motility.
Dysregulation of ARHGAP26 has been implicated in various diseases, including cancer, neurodevelopmental disorders, and cardiovascular diseases. Studying the function of ARHGAP26 using this antibody can provide valuable insights into its role in these pathological processes.Overall, the ARHGAP26 Polyclonal Antibody (PACO43679) is a valuable tool for researchers interested in unraveling the mechanisms underlying cell adhesion and migration, with potential implications for understanding and treating a wide range of diseases.
Antibody Name:
ARHGAP26 Antibody (PACO43679)
Antibody SKU:
PACO43679
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Rho GTPase-activating protein 26 protein (625-814AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43679 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO43679 at dilution of 1:100.
Background:
GTPase-activating protein for RHOA and CDC42.
Synonyms:
Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26), ARHGAP26, GRAF KIAA0621 OPHN1L
UniProt Protein Function:
ARHGAP26: GTPase-activating protein for RHOA and CDC42. Interacts with NYAP1, NYAP2 and MYO16. Binds to the C-terminus of PTK2/FAK1. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs; GAPs, Rac/Rho; Oncoprotein; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 5q31Cellular Component: cytosolMolecular Function: GTPase activator activity; phospholipid binding; protein bindingBiological Process: regulation of small GTPase mediated signal transductionDisease: Juvenile Myelomonocytic Leukemia
UniProt Protein Details:
NCBI Summary:
Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
