The ARHGAP18 Polyclonal Antibody (PACO07820) is a valuable tool for researchers studying the ARHGAP18 protein, a key regulator of cell migration and cytoskeletal organization. This antibody, produced in rabbits, exhibits high sensitivity and specificity when detecting ARHGAP18 in human samples, making it ideal for use in Western blot experiments.ARHGAP18 is involved in the control of cell morphology and movement, making it a crucial player in processes like cell migration and invasion. Dysregulation of ARHGAP18 has been linked to cancer progression and metastasis, making it a promising target for cancer research.
By using the ARHGAP18 Polyclonal Antibody, researchers can accurately detect and analyze ARHGAP18 expression in various cell types, furthering our understanding of its role in cancer biology.Additionally, the ARHGAP18 Polyclonal Antibody can be a valuable tool for studying other cellular processes involving ARHGAP18, such as cell adhesion, cell division, and signal transduction pathways. Its versatility and reliability make it an essential reagent for investigations in cell biology, cancer biology, and other areas of biomedical research.
Rho GTPase activating protein 18;ARHGAP18;FLJ25728;MGC126757;MGC138145;MacGAP;bA307O14.2 ;
UniProt Protein Function:
ARHGAP18: a GTPase activator for the Rho-type GTPases, converting them to inactive GDP-bound states. Two alternatively-spliced isoforms have been described.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 6q22.33Cellular Component: cytoplasm; cytosolMolecular Function: GTPase activator activityBiological Process: regulation of actin cytoskeleton organization and biogenesis; regulation of actin filament polymerization; regulation of cell shape; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
ARHGAP18 belongs to a family of Rho (see MIM 165390) GTPase-activating proteins that modulate cell signaling (Potkin et al., 2009 [PubMed 19065146]).[supplied by OMIM, Apr 2010]
