The ARHGAP17 Polyclonal Antibody (PAC022568) is a key tool for researchers studying ARHGAP17, a protein involved in cell migration and cytoskeletal organization. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By binding to ARHGAP17, it enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and cancer research.ARHGAP17, also known as Rho GTPase-activating protein 17, is essential for proper cell movement and adhesion, making it a crucial player in processes such as wound healing and metastasis. Its role in regulating cell shape and motility has important implications for understanding cancer progression and metastasis.
By studying the function of ARHGAP17, researchers can gain insights into potential therapeutic targets for inhibiting cancer cell migration and invasion.Overall, the ARHGAP17 Polyclonal Antibody is a valuable tool for researchers interested in unraveling the mechanisms of cell migration and invasion in various diseases, particularly cancer. Its specificity and reliability make it a trusted antibody for research in cell biology and cancer biology, leading to potential advancements in therapeutic interventions targeting ARHGAP17 function.
Antibody Name:
ARHGAP17 Antibody (PACO22568)
Antibody SKU:
PACO22568
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from internal of humanRHG17.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from LOVO cells, using RHG17 antibody.
Background:
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca2+-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.
Synonyms:
NADRIN; neuron-associated developmentally regulated protein; RHG17; rho GTPase activating protein 17; RhoGAP interacting with CIP4 homologs 1
UniProt Protein Function:
ARHGAP17: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1. 7 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: GTPase activator activity; protein bindingBiological Process: regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
