The ARHGAP17 Polyclonal Antibody (PACO4685) is specially designed for researchers studying ARHGAP17, a key protein involved in cell signaling pathways and cellular processes. This antibody, produced in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By binding to the ARHGAP17 protein, researchers can accurately detect and analyze this protein in a variety of cell types, making it an essential tool for investigations in cell biology and cancer research.ARHGAP17, also known as Rho GTPase-activating protein 17, plays a crucial role in regulating the activity of Rho GTPases, which are essential for cell morphology, migration, and signaling.
The importance of ARHGAP17 in cellular processes makes it a promising target for studying diseases such as cancer, where dysregulation of cell signaling pathways contributes to tumor progression. Discovering the functions and mechanisms of ARHGAP17 can provide valuable insights for developing novel therapies targeting Rho GTPase signaling in cancer and other related disorders.
Antibody Name:
ARHGAP17 Antibody
Antibody SKU:
PACO04685
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human ARHGAP17.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ARHGAP17; RICH1; MSTP066; MSTP110; Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs protein 1; RICH-1
UniProt Protein Function:
ARHGAP17: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1. 7 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, Rac/Rho; GAPsChromosomal Location of Human Ortholog: 16p12.1Cellular Component: cytosolMolecular Function: GTPase activator activity; protein bindingBiological Process: regulation of small GTPase mediated signal transduction
UniProt Protein Details:
NCBI Summary:
RICH1 is a GTPase-activating protein (GAP). GAPs stimulate the intrinsic GTP hydrolysis of small G proteins, such as RHOA (MIM 165390), RAC1 (MIM 602048), and CDC42 (MIM 116952).[supplied by OMIM, Apr 2004]
