The AQP6 Polyclonal Antibody (PAC048558) is a vital tool for researchers studying aquaporin 6, a water channel protein that plays a key role in water transport in the kidneys and lungs. This antibody, produced in rabbits, has high specificity and sensitivity when detecting AQP6 in human samples, making it an excellent choice for Western blot applications. By binding to AQP6, this antibody enables researchers to analyze and quantify the expression of this protein in various cell types, facilitating investigations in the fields of physiology, nephrology, and pulmonary biology.
Aquaporin 6 is essential for maintaining water balance in the body and is involved in regulating fluid secretion in the kidneys and airways. Dysfunction of AQP6 has been implicated in various conditions, such as kidney disorders and pulmonary edema, making it a valuable target for research in these areas. By studying the expression and function of AQP6, researchers can gain insights into the pathophysiology of these diseases and potentially identify new therapeutic targets for intervention.
Immunohistochemistry of paraffin-embedded human lung cancer using PACO48558 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO48558 at dilution of 1:100.
Background:
Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid, base metabolism.
AQP6: Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family.Protein type: Transporter; Transporter, aquaporin family; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12q13
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008]
