The APOLD1 Polyclonal Antibody (PACO62591) is a valuable tool for researchers studying the APOLD1 protein, which is involved in lipid metabolism and has been implicated in various diseases, including cardiovascular disorders and obesity. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the APOLD1 protein, researchers can detect and analyze its expression in a variety of cell types, making it ideal for studies in metabolism and disease mechanisms.
APOLD1, also known as apolipoprotein L domain-containing protein 1, plays a crucial role in lipid metabolism and the regulation of cholesterol levels. Its involvement in cardiovascular health and metabolic disorders makes it a promising target for research aimed at understanding and treating these conditions. By investigating the function of APOLD1, researchers can uncover potential therapeutic strategies for diseases related to lipid metabolism and cardiovascular health, ultimately contributing to the advancement of personalized medicine approaches.
Antibody Name:
APOLD1 Antibody (PACO62591)
Antibody SKU:
PACO62591
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Apolipoprotein L domain-containing protein 1 protein (213-274AA)
Immunofluorescence staining of Hela cells with PACO62591 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood-brain permeability.
Synonyms:
Apolipoprotein L domain-containing protein 1 (Vascular early response gene protein), APOLD1, VERGE
UniProt Protein Function:
APOLD1: May be involved in angiogenesis. May play a role in activity-dependent changes of brain vasculature. May affect blood- brain permeability. Belongs to the apolipoprotein L family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid-binding; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 12p13.1Cellular Component: plasma membrane; extracellular region; integral to membraneMolecular Function: lipid bindingBiological Process: response to hypoxia; lipoprotein metabolic process; angiogenesis; cell differentiation; lipid transport; regulation of endothelial cell differentiation; endothelial cell activation
UniProt Protein Details:
NCBI Summary:
APOLD1 is an endothelial cell early response protein that may play a role in regulation of endothelial cell signaling and vascular function (Regard et al., 2004 [PubMed 15102925]).[supplied by OMIM, Dec 2008]
