The APBB2 Polyclonal Antibody (PACO07777) is a valuable tool for researchers studying the APBB2 protein, which is involved in numerous cellular processes, including signal transduction and protein binding. The antibody is raised in rabbits and has high reactivity with human samples, making it ideal for Western blot applications. By binding to the APBB2 protein, this antibody enables precise detection and analysis in various cell types, making it essential for studies in molecular biology and cell signaling pathways.APBB2, also known as amyloid beta precursor protein-binding family B member 2, plays a key role in mediating protein-protein interactions and modulating cellular functions.
Its involvement in signaling cascades and intracellular communication makes it a promising target for research into neurodegenerative diseases, such as Alzheimer's disease, where protein misfolding and aggregation are major factors. Investigating the role of APBB2 can provide valuable insights into disease mechanisms and potential therapeutic strategies targeting protein interactions and signaling pathways.
amyloid β (A4) precursor protein-binding, family B, member 2;APBB2;DKFZp434E033;FE65L;FE65L1;MGC35575 ;
UniProt Protein Function:
APBB2: May modulate the internalization of beta-amyloid precursor protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: ApoptosisChromosomal Location of Human Ortholog: 4p13Cellular Component: cytoplasm; growth cone; lamellipodium; membrane; nucleus; synapseMolecular Function: beta-amyloid binding; protein binding; transcription factor bindingBiological Process: axon guidance; cell cycle arrest; extracellular matrix organization and biogenesis; negative regulation of apoptosis; negative regulation of cell growth; neuron migration; positive regulation of apoptosis; regulation of transcription, DNA-dependentDisease: Alzheimer Disease
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
