The Anti-TUG/ASPSRC1 Polyclonal Antibody (CAB1396) is specifically designed for research involving TUG (Tubby family member 3) and ASPSRC1 (ankyrin repeat and suppressor of cytokine signaling box-containing protein 1), two proteins implicated in various cellular processes, including gene transcription and signal transduction pathways. The antibody, generated in rabbits, demonstrates high specificity and sensitivity in detecting TUG and ASPSRC1 in human samples, making it a valuable tool for immunology and cancer research studies.TUG and ASPSRC1 are essential regulators of gene expression and cellular signaling, playing key roles in cell growth, differentiation, and survival pathways. Dysregulation of these proteins has been linked to various diseases, including cancer, diabetes, and neurological disorders.
By targeting TUG and ASPSRC1, researchers can better understand the molecular mechanisms underlying these diseases and develop targeted therapies to modulate their activity.Utilizing the Anti-TUG/ASPSRC1 Polyclonal Antibody (CAB1396) in Western blot applications allows for the precise detection and quantification of TUG and ASPSRC1 levels in different cell types, providing valuable insights into their functions in normal physiology and disease states. This antibody is a valuable tool for researchers investigating the roles of TUG and ASPSRC1 in cellular processes and disease pathogenesis, ultimately leading to the development of novel therapeutic approaches targeting these proteins.
Product Name:
TUG Rabbit Monoclonal Antibody
SKU:
CAB1396
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human TUG/ASPSCR1 (Q9BZE9).
The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found.
Purification Method:
Affinity purification
Gene ID:
79058
Clone Number:
ARC2566
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various lysates, using TUG/ASPSCR1 antibody (CAB1396) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
