TAX1BP3 Rabbit Monoclonal Antibody (CAB19793)
- SKU:
- CAB19793
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- TIP-1
- TIP1
- Research Area:
- Metabolism
Description
Product Name: | TAX1BP3 Rabbit Monoclonal Antibody |
SKU: | CAB19793 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TAX1BP3 (NP_055419.1). |
Sequence: | MSYI PGQP VTAV VQRV EIHK LRQG ENLI LGFS IGGG IDQD PSQN PFSE DKTD KGIY VTRV SEGG PAEI AGLQ IGDK IMQV NGWD MTMV THDQ ARKR LTKR |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | TIP1; TIP-1; TAX1BP3 |
Positive Sample: | MCF7,NIH/3T3,Mouse lung,Mouse heart,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, fibrillar center, plasma membrane |
Calculated MW: | 14kDa |
Observed MW: | 14kDa |
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 30851 |
Clone Number: | ARC2319 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |