The Tax1BP3 Polyclonal Antibody (CAB19793) is a powerful tool for researchers studying Tax1BP3, a protein involved in various cellular processes, including autophagy and tumor suppression. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in Western blotting and other immunological techniques. By targeting the Tax1BP3 protein, researchers can accurately detect and analyze its expression in different cell types, providing valuable insights into its role in autophagy-related pathways and cancer biology.Tax1BP3, also known as Tax1 binding protein 3, has been shown to play a critical role in the regulation of autophagy, a cellular process that helps maintain cellular homeostasis by degrading damaged organelles and proteins.
Dysregulation of autophagy has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases. Therefore, understanding the function of Tax1BP3 is essential for developing potential therapeutic interventions that target autophagy pathways in these pathological conditions.Overall, the Tax1BP3 Polyclonal Antibody (CAB19793) offers researchers a valuable tool for investigating the molecular mechanisms underlying autophagy and its implications in disease development. Its high specificity and reliability make it an essential component in immunological studies aimed at unraveling the complexities of cellular processes and potential therapeutic targets.
Product Name:
TAX1BP3 Rabbit Monoclonal Antibody
SKU:
CAB19793
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human TAX1BP3 (NP_055419.1).
actin cytoskeleton, cytoplasm, cytosol, extracellular exosome, fibrillar center, plasma membrane
Calculated MW:
14kDa
Observed MW:
14kDa
This gene encodes a small, highly conserved protein with a single PDZ domain. PDZ (PSD-95/Discs large/ZO-1 homologous) domains promote protein-protein interactions that affect cell signaling, adhesion, protein scaffolding, and receptor and ion transporter functions. The encoded protein interacts with a large number of target proteins that play roles in signaling pathways; for example, it interacts with Rho A and glutaminase L and also acts as a negative regulator of the Wnt/beta-catenin signaling pathway. This protein was first identified as binding to the T-cell leukaemia virus (HTLV1) Tax oncoprotein. Overexpression of this gene has been implicated in altered cancer cell adhesion, migration and metastasis. The encoded protein also modulates the localization and density of inwardly rectifying potassium channel 2.3 (Kir2.3). To date, this protein has been shown to play a role in cell proliferation, development, stress response, and polarization. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
30851
Clone Number:
ARC2319
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using TAX1BP3 Rabbit mAb (CAB19793) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
