The SLFN11 Polyclonal Antibody (CAB20490) is a valuable tool for researchers studying SLFN11, a protein known for its role in DNA damage response and its potential as a biomarker for cancer therapy. This rabbit-derived antibody exhibits high reactivity with human samples and has been validated for use in Western blot applications.SLFN11, a member of the Schlafen family of proteins, has been shown to inhibit protein synthesis and promote cell death in response to DNA damage. Its presence has been correlated with increased sensitivity to certain cancer treatments, making it a promising target for further investigation in cancer research.
By specifically binding to the SLFN11 protein, this antibody enables researchers to study its expression and function in various cell types, providing valuable insights into its role in DNA repair mechanisms and its potential as a therapeutic target. This antibody is a valuable tool for researchers interested in understanding the molecular mechanisms underlying cancer development and treatment resistance.
Product Name:
SLFN11 Rabbit Polyclonal Antibody
SKU:
CAB20490
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 132-328 of human SLFN11 (NP_689483.3).
Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage.
Purification Method:
Affinity purification
Gene ID:
91607
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLFN11 antibody (CAB20490) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
