The SLC22A3 (OCT3) Polyclonal Antibody (CAB19758) is a valuable tool for researchers studying the SLC22A3 protein, also known as Organic Cation Transporter 3. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.SLC22A3 is a membrane protein involved in the transport of organic cations across cell membranes, influencing the pharmacokinetics and pharmacodynamics of various drugs. Its role in drug transport and disposition makes it a key target for research in pharmacology and personalized medicine. By using this antibody to detect and analyze the SLC22A3 protein in various cell types, researchers can gain insights into drug transport mechanisms and the impact of SLC22A3 on drug efficacy and toxicity.
Furthermore, the SLC22A3 protein has been implicated in diseases such as diabetes, cancer, and cardiovascular disorders, highlighting its relevance as a potential therapeutic target. A deeper understanding of the function and regulation of SLC22A3 could lead to the development of novel treatments for these conditions. By utilizing the SLC22A3 Polyclonal Antibody in their studies, researchers can advance our knowledge of drug transport processes and potential therapeutic interventions.
Product Name:
SLC22A3/OCT3 Rabbit Monoclonal Antibody
SKU:
CAB19758
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 301-450 of human SLC22A3/OCT3 (O75751).
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.
Purification Method:
Affinity purification
Gene ID:
6581
Clone Number:
ARC2285
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using SLC22A3/OCT3 Rabbit mAb (CAB19758) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
