The Anti-Siglec7 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0301) is a powerful tool for researchers studying Siglec7, a cell surface molecule involved in immune regulation. This antibody, developed using innovative chimeric recombinant technology, boasts high specificity and sensitivity in the detection of Siglec7 protein in human samples. With its superior performance in Western blot applications, this antibody enables precise analysis of Siglec7 expression in various cell types. Its unique properties make it an ideal choice for investigations in immunology and cancer research, shedding light on the role of Siglec7 in immune responses and potential implications for disease pathogenesis.
Moreover, as Siglec7 has been implicated in modulating immune function and inflammatory responses, the Anti-Siglec7 Chimeric Recombinant Rabbit Monoclonal Antibody holds promise for unveiling new insights into the mechanisms underlying autoimmune disorders, cancer progression, and other inflammatory conditions. Its application in research may ultimately lead to the development of targeted therapies that manipulate Siglec7 activity for therapeutic benefit.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34 cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).[UniProtKB/Swiss-Prot Function]
