The Anti-PMEL Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0264) offered by Assay Genie is a cutting-edge tool for researchers studying PMEL, a key protein involved in melanosome biogenesis and melanin synthesis. This antibody, developed using advanced chimeric recombinant technology, boasts high specificity and sensitivity in detecting PMEL in various biological samples.PMEL, also known as Pmel17 or gp100, is essential for the formation of melanosomes, which are responsible for melanin production and distribution in melanocytes. Aberrant expression or dysfunction of PMEL has been implicated in various skin conditions and melanoma progression, making it a promising target for therapeutic interventions.
The unique properties of the Anti-PMEL Chimeric Recombinant Rabbit Monoclonal Antibody make it an invaluable tool for investigating PMEL expression levels, localization, and interactions in different cell types and tissues. Its superior performance in applications such as immunofluorescence, immunohistochemistry, and flow cytometry make it a versatile choice for researchers in the fields of dermatology, oncology, and cell biology. Unlock the potential of PMEL research with this innovative antibody from Assay Genie.
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
