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Phospho-STAT5A-S780 Rabbit Polyclonal Antibody (CABP0139)

SKU:
CABP0139
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MGF
STAT5
STAT5A
Research Area:
Cell Biology
$503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-STAT5A-S780 Rabbit Polyclonal Antibody
SKU:CABP0139
Size:100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A phospho specific peptide corresponding to residues surrounding S780 of human STAT5A
Tested Applications:WB
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:MGF; STAT5; Phospho-STAT5A-S780
Positive Sample:K-562
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Nucleus.
Calculated MW:91kDa
Observed MW:91kDa

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.

Purification Method:Affinity purification
Gene ID:6776
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from K562 cells using Phospho-STAT5A-S780 Rabbit pAb (CABP0139).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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