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Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin

SKU:
IVMB0048
Product Type:
In Vivo Monoclonal Antibody
Clone:
9H10
Protein:
CLTA-4
Isotype:
Syrian Hamster IgG
Reactivity:
Mouse
Synonyms:
CD152
Cytotoxic T Lymphocyte-Associated Antigen-4
Ly-56
Research Area:
Immune Checkpoint & Cancer Biology
Endotoxin Level:
Ultra Low Endotoxin
Host Species:
Syrian Hamster
Applications:
Blocking
WB
$322 - $4,939
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Description

system_update_altTechnical Datasheet

Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin

Introducing the Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin from Assay Genie, a powerful monoclonal antibody specifically designed for in vivo applications. This antibody targets the CTLA-4 protein, which plays a critical role in the regulation of immune responses, making it an essential tool for immunology and related research fields. With a rat IgG2b isotype, it guarantees high purity and ultra-low endotoxin levels (<0.01 EU/mg), ensuring minimal interference in your experiments and making it highly suitable for a wide range of assays including ELISA, flow cytometry, immunohistochemistry, and others. The Ultra Low Endotoxin format is specially formulated in phosphate-buffered saline to provide stability and maximize efficacy.

It is available in various sizes to meet the specific needs of your research projects. This antibody is designed to facilitate groundbreaking research by offering unmatched reliability and versatility. CTLA-4 is an inhibitory receptor found on T-cells that plays an important role in downregulating immune responses. By binding to CD80 and CD86 on antigen-presenting cells, CTLA-4 competes with the costimulatory receptor CD28, thus playing a crucial part in maintaining immune homeostasis and preventing autoimmune reactions. Elevate your research with the Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin and make significant strides in understanding immune regulation and potential therapeutic approaches.

Product Name:Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low Endotoxin
Product Code:IVMB0048
Size:1mg, 5mg, 25mg, 50mg, 100mg
Clone:9H10
Protein:CLTA-4
Product Type:Monoclonal Antibody
Synonyms:CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype:Syrian Hamster IgG
Reactivity:Mouse
Immunogen:Mouse CTLA-4-human IgG1 fusion protein
Applications:B, WB
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.
Product CodeProduct NameEndotoxin Level
IVMB0047Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Low EndotoxinLow
IVMB0048Anti-Mouse CTLA-4 [9H10] In Vivo Antibody - Ultra Low EndotoxinUltra Low
Applications:B, WB
Reactivity:Mouse
Host Species:Syrian Hamster
Specificity:Anti-Mouse CLTA-4 (Clone 9H10) recognizes an epitope on Mouse CD152. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. This antibody was also pathogen tested and third-party certified by IDEXX BioReseach to meet the lowest mycoplasma specification and free of any viral pathogens of concern.
Antigen Distribution:Activated T cells
Immunogen:Mouse CTLA-4-human IgG1 fusion protein
Concentration:≥ 5.0 mg/ml
Endotoxin Level:<0.5 EU/mg as determined by the LAL method
Purity:≥98% monomer by analytical SEC
>95% by SDS Page
Formulation:This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
Preparation:Functional grade preclinical antibodies are manufactured in an animal free facility using only In vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.
Storage and Handling:Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles.

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system.1 CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells.2,3 CTLA4 is potentially therapeutic in autoimmune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. The 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding.

Technical Datasheet:View
Protein:CLTA-4
Function:Negative regulator of T cell activation
Ligand/Receptor:CD80 (B7.1), CD86 (B7.2)
Research Area:Immunology

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