The MEF2A/MEF2C Polyclonal Antibody (CAB2710) is a valuable tool for researchers studying the MEF2A and MEF2C transcription factors, key regulators of gene expression in various biological processes. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications.MEF2A and MEF2C play important roles in cell differentiation, growth, and survival, making them critical targets for research in developmental biology, neurobiology, and cardiac biology. The antibody binds to MEF2A and MEF2C proteins, allowing for their detection and analysis in different cell types and tissues.
Understanding the functions and regulatory mechanisms of MEF2A and MEF2C is essential for unraveling their roles in normal physiology and disease processes. This antibody provides a reliable tool for studying these transcription factors, offering valuable insights into their involvement in various cellular processes and diseases such as cancer, cardiovascular disorders, and neurological conditions.
Product Name:
MEF2A+MEF2C Rabbit Monoclonal Antibody
SKU:
CAB2710
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 250-473 of human MEF2A+MEF2C (Q06413).
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.The protein encoded by this gene is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this gene could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1). Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4208/4205
Clone Number:
ARC2661
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using MEF2A+MEF2C Rabbit mAb (CAB2710) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
