The LMO2 Polyclonal Antibody (CAB6832) is a valuable tool for researchers studying the LMO2 protein, a transcription factor involved in hematopoiesis and leukemia. This antibody, raised in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.LMO2 plays a crucial role in normal hematopoietic development, but its dysregulation is associated with leukemia and other hematological malignancies. Understanding the expression and function of LMO2 in different cell types can provide insights into the mechanisms driving these diseases and potentially lead to the development of targeted therapies.
With its specificity and reliability, the LMO2 Polyclonal Antibody is an essential tool for researchers investigating the role of LMO2 in both normal and pathological hematopoiesis. Its versatility and sensitivity make it suitable for a wide range of experimental settings, making it a valuable asset in the fields of oncology and hematology research.
Product Name:
LMO2 Rabbit Monoclonal Antibody
SKU:
CAB6832
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LMO2 (P25791).
LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4005
Clone Number:
ARC1422
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using LMO2 antibody (CAB6832) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
