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Anti-HTR2A Antibody (CAB20538)

SKU:
CAB20538
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
HTR2
5-HT2A
€139 - €419
Frequently bought together:

Description

Anti-HTR2A Antibody (CAB20538)

The Anti-HTR2A Antibody (CAB20538) is a valuable tool for researchers studying the HTR2A protein, a serotonin receptor involved in various physiological processes including neurotransmission and mood regulation. This polyclonal antibody is produced in rabbits and exhibits high reactivity with human samples, making it a reliable choice for Western blot applications.By targeting the HTR2A protein, this antibody allows for the detection and analysis of HTR2A expression in different cell types, offering insights into its role in psychiatric disorders, neurodegenerative diseases, and drug responses.

The HTR2A receptor is a key player in serotonin signaling, making it a promising target for drug development and therapeutic interventions.With its potential applications in neuroscience, pharmacology, and psychiatry research, the Anti-HTR2A Antibody (CAB20538) is a valuable tool for investigating the complex functions of the HTR2A receptor and its implications in various disorders and treatments.

Product Name:HTR2A Rabbit pAb
Product Code:CAB20538
Size:50uL, 100uL
Synonyms:HTR2, 5-HT2A
Applications:WB, IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant protein of human HTR2A.
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:SH-SY5Y, Mouse brain
Immunogen:Recombinant protein of human HTR2A.
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3356
Uniprot:P28223
Calculated MW:52kDa
Observed MW:53KDa
UniProt Protein Function:5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 13q14-q21 Cellular Component: cell soma; axon; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane; dendritic shaft; caveola; cytosol Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding Biological Process: cell death; urinary bladder smooth muscle contraction; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; positive regulation of MAP kinase activity; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; artery smooth muscle contraction; serotonin receptor signaling pathway; regulation of behavior; aging; response to drug; serotonin receptor, phospholipase C activating pathway; regulation of hormone secretion; negative regulation of synaptic transmission, glutamatergic; positive regulation of phosphatidylinositol biosynthetic process; sleep; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder
UniProt Protein Details:
NCBI Summary:This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Code:P28223
NCBI GenInfo Identifier:543727
NCBI Gene ID:3356
NCBI Accession:P28223.2
UniProt Secondary Accession:P28223,Q5T8C0, B2RAC5, B4DZ79, F5GWE8
UniProt Related Accession:P28223
Molecular Weight:
NCBI Full Name:5-hydroxytryptamine receptor 2A
NCBI Synonym Full Names:5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
NCBI Official Symbol:HTR2A  
NCBI Official Synonym Symbols:HTR2; 5-HT2A  
NCBI Protein Information:5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor
UniProt Protein Name:5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names:Serotonin receptor 2A
Protein Family:
UniProt Gene Name:HTR2A  
UniProt Entry Name:5HT2A_HUMAN

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