The Anti-CXCR2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0329) is a cutting-edge tool for researchers studying CXCR2, a chemokine receptor involved in inflammation and immune responses. This antibody, developed using advanced recombinant technology, exhibits high specificity and sensitivity for detecting CXCR2 in various cell types.CXCR2 is a key player in the recruitment of neutrophils to sites of inflammation, making it a potential target for therapeutic intervention in inflammatory diseases, such as rheumatoid arthritis and asthma. The Anti-CXCR2 antibody enables precise detection and analysis of CXCR2 expression levels, aiding researchers in understanding its role in disease pathology and immune regulation.
With its superior performance in techniques like Western blotting and immunohistochemistry, the Anti-CXCR2 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0329) is a valuable tool for investigations into inflammatory signaling pathways and the development of novel therapeutic strategies targeting CXCR2. Trust in this antibody to provide reliable results and propel your research forward in the fields of immunology and inflammation.
SKU:
HDAB0329
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC681
Synonyms:
CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]
