The Anti-Coenzyme NAD+ Antibody (CAB21047) is a high-quality polyclonal antibody designed for research involving coenzyme NAD+ (nicotinamide adenine dinucleotide), a critically important molecule involved in various cellular processes, such as energy production and metabolism. This antibody, produced in rabbits, is highly specific and reactive with human samples, making it suitable for a wide range of applications in the study of NAD+ biology.Coenzyme NAD+ is a key player in cellular redox reactions, DNA repair, and cell signaling pathways, making it a crucial molecule in physiological and pathological processes. The Anti-Coenzyme NAD+ Antibody binds specifically to NAD+, enabling precise detection and analysis in various cell types and tissues.
This antibody is validated for use in techniques such as immunohistochemistry and ELISA, providing researchers with a reliable tool for investigating the role of NAD+ in health and disease.With its ability to target coenzyme NAD+, this antibody is particularly valuable in studies related to aging, metabolism, neurodegenerative diseases, and cancer, where NAD+ levels and functions are known to be dysregulated. By understanding the dynamics of NAD+ and its interactions with other molecules, researchers can uncover new insights into cellular processes and potentially develop novel therapeutic strategies targeting NAD+ metabolism.
Product Name:
Coenzyme NAD Monoclonal Antibody
SKU:
CAB21047
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Species independent
Immunogen:
NAD
Tested Applications:
ELISADB
Recommended Dilution:
DB,1:500 - 1:1000
Positive Sample:
Coenzyme NAD
Conjugate:
Unconjugated
Observed MW:
Refer to figures
The coenzyme NAD is involved in oxidation–reduction reactions critical for glycolysis, fatty acid oxidation, the TCA cycle, and complex I of the mitochondrial respiratory chain and also is a key regulator of autophagy. At least two different mechanisms are involved. First, the NAD+-dependent deacetylase SIRT1 activates autophagy by directly deacetylating ATG proteins. Under starvation conditions, the increased NAD+/NADH ratio activates SIRT1, which results in stimulation of mitophagy. Second, the hydrogen of NADH can be transferred to NADP+ to form NADPH via the energy-linked transhydrogenase. In the fed state, when the NAD+/NADH ratio falls, NADPH inhibits autophagy by scavenging of ROS via the glutathione peroxidase-glutathione reductase system and by preventing the production of ROS at complex 1 of the respiratory chain.
Purification Method:
Affinity purification
Gene ID:
CAS:53-84-9
Clone Number:
ARC51050
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
The Coenzyme NAD Rabbit mAb (CAB21047) are tested in Dot Blot against NAD and deoxynucleotide,adenosine.m6A 8 - ATAACTGG-m6A-CCGAATGGm6A 9 - ATAACTGGACCGAATGG
