The Anti-CD142 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0289) is a cutting-edge tool for researchers studying CD142, a protein involved in the coagulation pathway and inflammation. This high-quality antibody, produced in rabbits, exhibits exceptional reactivity with human samples and is validated for use in various applications, including Western blotting.CD142, also known as tissue factor, plays a crucial role in blood clotting and has implications in the regulation of inflammatory responses. By targeting the CD142 protein, researchers can effectively detect and analyze its expression in different cell types, making it a valuable asset for studies in immunology and thrombosis research.
The Anti-CD142 Chimeric Recombinant Rabbit Monoclonal Antibody (HDAB0289) is essential for investigating the function of CD142 in various disease contexts, such as cardiovascular disorders, sepsis, and cancer. Its specificity and reliability make it a key tool for unraveling the complex mechanisms underlying coagulation and inflammation, paving the way for the development of targeted therapies and diagnostic tools.
SKU:
HDAB0289
Size:
100 µg
Clonality:
Monoclonal
Clone:
DMC463
Synonyms:
TF, Coagulation factor III, F3
Applications:
Flow Cyt
Recommended Dilution:
Flow Cyt 1:100
Host Species:
Rabbit
Isotype:
Rabbit/Human Fc chimeric IgG1
Reactivity:
Human
Purification Method:
Purified from cell culture supernatant by affinity chromatography
Formulation:
Powder
Buffer:
1XPBS
Storage:
Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized antibodies are shipped at ambient temperature.
Usage:
Research use only
Background:
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
