The Anti-Caspr1 Antibody (CAB3721) is a high-quality antibody specifically designed for research involving Caspr1, a cell adhesion molecule that plays a crucial role in the organization of the nodes of Ranvier in the nervous system. The antibody, produced using advanced technology, demonstrates high specificity and sensitivity towards Caspr1 in various biological samples, making it an ideal tool for immunohistochemistry, immunofluorescence, and other research applications.Caspr1, also known as Contactin-associated protein 1, is essential for the formation and maintenance of the nodes of Ranvier, which are crucial for the proper functioning of nerve cells.
Dysregulation of Caspr1 has been linked to neurological disorders such as multiple sclerosis and schizophrenia, making it a valuable target for research in neuroscience and neurology. By using the Anti-Caspr1 Antibody, researchers can accurately detect and analyze Caspr1 expression in different tissues and cell types, providing valuable insights into its role in neurodevelopment and disease pathology. Overall, the Anti-Caspr1 Antibody (CAB3721) is a reliable and effective tool for researchers studying Caspr1 and its implications in neurological disorders, offering exceptional performance and consistent results in a wide range of experimental settings.
Product Name:
Caspr1 Rabbit Monoclonal Antibody
SKU:
CAB3721
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human Caspr11 (P78357).
glutamatergic synapse, paranodal junction, plasma membrane, presynaptic active zone
Calculated MW:
156kDa
Observed MW:
190kDa
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.
Purification Method:
Affinity purification
Gene ID:
8506
Clone Number:
ARC2084
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of U-87MG cells, using Caspr11 Rabbit mAb (CAB3721) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
