The ALPL Monoclonal Antibody (PACO33760) is a powerful tool for researchers studying ALPL, an essential enzyme involved in bone mineralization and phosphate metabolism. This antibody, produced using state-of-the-art technology, specifically targets human ALPL and is validated for use in various applications such as Western blotting and immunohistochemistry.ALPL, also known as tissue-nonspecific alkaline phosphatase, plays a crucial role in maintaining bone health and proper mineralization.
Mutations in the ALPL gene have been linked to a variety of skeletal and mineralization disorders, making it a key target for investigation in the fields of bone biology and mineral metabolism. The ALPL Monoclonal Antibody enables precise detection and quantification of ALPL levels in a wide range of sample types, making it an invaluable tool for research into skeletal disorders, metabolic diseases, and related conditions.
Antibody Name:
Alpl Antibody (PACO33760)
Antibody SKU:
PACO33760
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Mouse
Immunogen:
Recombinant Mouse Alkaline phosphatase, tissue-nonspecific isozyme protein (20-503AA)
This isozyme may play a role in skeletal mineralization.
UniProt Protein Details:
NCBI Summary:
This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
