The Alg12 Polyclonal Antibody (PAC042102) is a valuable tool for researchers studying the Alg12 protein, a key enzyme involved in the synthesis of dolichol-linked oligosaccharides. This antibody, produced in rabbits, demonstrates high specificity and reactivity with human samples, making it an ideal choice for Western blot applications.The Alg12 protein plays a crucial role in the glycosylation pathway, specifically in the transfer of glucose residues to dolichol phosphate. Dysregulation of this process has been linked to various genetic disorders and diseases, making Alg12 a target of interest for research in glycobiology and metabolic disorders.
By utilizing the Alg12 Polyclonal Antibody, researchers can accurately detect and analyze Alg12 protein levels in different cell types, providing valuable insights into its function and potential implications in disease pathology. This antibody is a valuable tool for studies in glycosylation pathways, metabolic diseases, and related research areas.
Immunohistochemistry of paraffin-embedded human skin tissue using PACO42102 at dilution of 1:100.
Immunofluorescent analysis of Hela cells using PACO42102 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.
Synonyms:
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (EC 2.4.1.260) (Asparagine-linked glycosylation protein 12 homolog) (hALG12) (Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl-alpha-1,6-mannosyltransferase) (Mannosyltransferase ALG12 homolog) (Membrane protein SB87), ALG12
UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig (CDG-Ig)characterized by abnormal N-glycosylation. [provided by RefSeq, Jul 2008]
