UniProt Protein Function: | ALG10: Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. Belongs to the ALG10 glucosyltransferase family.Protein type: Glycan Metabolism - N-glycan biosynthesis; EC 2.4.1.256; Membrane protein, integral; Membrane protein, multi-pass; TransferaseChromosomal Location of Human Ortholog: 12p11.1Disease: Long Qt Syndrome 2 |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010] |
UniProt Code: | Q5BKT4 |
NCBI GenInfo Identifier: | 74736030 |
NCBI Gene ID: | 84920 |
NCBI Accession: | Q5BKT4.1 |
UniProt Secondary Accession: | Q5BKT4,Q6NS98, Q96DU0, Q96SM6 |
UniProt Related Accession: | Q5BKT4 |
Molecular Weight: | 55,606 Da |
NCBI Full Name: | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase |
NCBI Synonym Full Names: | ALG10, alpha-1,2-glucosyltransferase |
NCBI Official Symbol: | ALG10Â Â |
NCBI Official Synonym Symbols: | DIE2; KCR1; ALG10AÂ Â |
NCBI Protein Information: | dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase |
UniProt Protein Name: | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase |
UniProt Synonym Protein Names: | Alpha-1,2-glucosyltransferase ALG10-A; Alpha-2-glucosyltransferase ALG10-A; Asparagine-linked glycosylation protein 10 homolog A |
Protein Family: | Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase |
UniProt Gene Name: | ALG10Â Â |
UniProt Entry Name: | AG10A_HUMAN |