ALDH2 Rabbit Polyclonal Antibody (CAB1226)
- SKU:
- CAB1226
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | ALDH2 Rabbit Polyclonal Antibody |
SKU: | CAB1226 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 321-480 of human ALDH2 (NP_000681.2). |
Sequence: | AGSR TFVQ EDIY DEFV ERSV ARAK SRVV GNPF DSKT EQGP QVDE TQFK KILG YINT GKQE GAKL LCGG GIAA DRGY FIQP TVFG DVQD GMTI AKEE IFGP VMQI LKFK TIEE VVGR ANNS TYGL AAAV FTKD LDKA NYLS QALQ AGTV WVNC YDVF GAQS |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ALDM; ALDHI; ALDH-E2; ALDH2 |
Positive Sample: | HepG2,A-549,Mouse liver,Mouse kidney,Rat liver,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 56kDa |
Observed MW: | 50-56kDa |
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 217 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |