The AKR7A2 Polyclonal Antibody (CAB1227) is a valuable tool for researchers studying AKR7A2, an enzyme that plays a key role in detoxification processes within the body. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the AKR7A2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it essential for studies in toxicology, pharmacology, and drug metabolism research.AKR7A2 is a member of the aldo-keto reductase superfamily and demonstrates significant activity in metabolizing various endogenous and exogenous compounds, including aldehydes and ketones.
Its involvement in detoxification pathways makes it a target of interest in understanding drug metabolism, chemical carcinogenesis, and oxidative stress responses. By elucidating the function of AKR7A2, researchers can gain insights into potential therapeutic interventions for conditions related to environmental toxin exposure and oxidative damage.
Product Name:
AKR7A2 Rabbit Polyclonal Antibody
SKU:
CAB1227
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-359 of human AKR7A2 (NP_003680.2).
The protein encoded by this gene belongs to the aldo/keto reductase (AKR) superfamily and AKR7 family, which are involved in the detoxification of aldehydes and ketones. The AKR7 family consists of 3 genes that are present in a cluster on the p arm of chromosome 1. This protein, thought to be localized in the golgi, catalyzes the NADPH-dependent reduction of succinic semialdehyde to the endogenous neuromodulator, gamma-hydroxybutyrate. It may also function as a detoxication enzyme in the reduction of aflatoxin B1 and 2-carboxybenzaldehyde. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8574
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using AKR7A2 antibody (CAB1227) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).
