The AKIP1 Polyclonal Antibody (PAC055274) is a valuable tool for researchers studying the AKIP1 protein, which is involved in cellular signaling pathways related to cancer progression. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to AKIP1, researchers can easily detect and analyze the protein in a variety of cell types, making it an essential component for studies in cancer biology and drug development.AKIP1, also known as A kinase interacting protein 1, plays a crucial role in promoting cell proliferation and survival through its interaction with protein kinases.
Its involvement in cancer cell growth and metastasis makes it a potential therapeutic target for combating malignancies. By investigating the function of AKIP1, researchers can uncover novel insights into cancer biology and identify new strategies for treating various types of cancer. The use of the AKIP1 Polyclonal Antibody is therefore essential for advancing our understanding of the role of AKIP1 in cancer and other diseases.
Antibody Name:
AKIP1 Antibody (PACO55274)
Antibody SKU:
PACO55274
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human A-kinase-interacting protein 1 protein (57-167AA)
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO55274 at dilution of 1:100.
Background:
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Synonyms:
A-kinase-interacting protein 1 (Breast cancer-associated gene 3 protein) (PKA-interacting protein) (Proline-rich protein BCA3), AKIP1, BCA3 C11orf17
UniProt Protein Function:
BCA3: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 11p15.3Cellular Component: nucleoplasmMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
