The AKIP1 Antibody (PAC023285) is a valuable tool for researchers studying AKIP1, a protein involved in the regulation of gene expression and cell proliferation. This polyclonal antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the AKIP1 protein, this antibody enables the detection and analysis of AKIP1 in various cell types, making it an essential reagent for studies in cell biology and cancer research.AKIP1, also known as A kinase-interacting protein 1, plays a crucial role in various cellular processes, including cell cycle progression and transcriptional regulation.
Dysregulation of AKIP1 has been implicated in the development and progression of cancer, making it a promising target for therapeutic intervention. Further understanding of the function and regulation of AKIP1 may lead to the development of novel treatment strategies for cancer and other diseases involving aberrant cell growth.In summary, the AKIP1 Antibody (PAC023285) is a reliable tool for researchers investigating the role of AKIP1 in cellular processes and disease mechanisms. Its high specificity and validation make it a valuable asset for studies aiming to unravel the complexities of AKIP1 function and its potential as a therapeutic target.
Synthesized peptide derived from internal of human BCA3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using BCA3 antibody.
Immunohistochemistry analysis of paraffin-embedded human heart tissue using BCA3 antibody.
Background:
Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade.
Synonyms:
Breast cancer-associated gene 3 protein; PKA-interacting protein; AKIP1;
UniProt Protein Function:
BCA3: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. 3 isoforms of the human protein are produced by alternative splicing.Protein type: OncoproteinChromosomal Location of Human Ortholog: 11p15.3Cellular Component: nucleoplasmMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
