The AGBL5 Polyclonal Antibody (PAC015343) is a valuable tool for researchers studying AGBL5, a protein involved in cellular processes such as cell division, migration, and invasion. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting AGBL5 in human samples, making it suitable for use in Western blot applications. By targeting the AGBL5 protein, this antibody enables precise identification and analysis of AGBL5 expression in different cell types, making it an essential tool for studies in cell biology and cancer research.
AGBL5, also known as ATP/GTP-binding protein-like 5, plays a crucial role in regulating cellular functions and has been implicated in cancer development and progression. Understanding the functions and mechanisms of AGBL5 can provide insights into tumor biology and potential therapeutic targets for cancer treatment. By using the AGBL5 Polyclonal Antibody, researchers can further explore the role of AGBL5 in various cellular processes and facilitate the development of novel strategies for cancer therapy.
Antibody Name:
AGBL5 Antibody (PACO15343)
Antibody SKU:
PACO15343
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human AGBL5
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15343(AGBL5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15343(AGBL5 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post-translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6.
Synonyms:
ATP/GTP binding protein-like 5
UniProt Protein Function:
AGBL5: Metallocarboxypeptidase that mediates tubulin deglutamylation. Specifically catalyzes the deglutamylation of the branching point glutamate side chains generated by post- translational glutamylation in proteins such as tubulins. In contrast, it is not able to act as a long-chain deglutamylase that shortens long polyglutamate chains, a process catalyzed by AGTPBP1/ CCP1, AGBL1/CCP4 and AGBL4/CCP6. Belongs to the peptidase M14 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.17.-; ProteaseChromosomal Location of Human Ortholog: 2p23.3Cellular Component: cytoplasm; cytosol; midbody; nucleusMolecular Function: metallocarboxypeptidase activity; tubulin bindingBiological Process: defense response to virus
UniProt Protein Details:
NCBI Summary:
This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
