The AGBL4 Polyclonal Antibody (PACO22298) is a valuable tool for researchers studying AGBL4, a protein involved in various cellular processes, including microtubule severing and cytoskeletal dynamics. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications.AGBL4, also known as ATP/GTP-binding protein-like 4, plays a crucial role in regulating cell division, cell morphology, and intracellular transport. Studies have shown its involvement in cancer progression, making it a promising target for cancer research and therapy development.
By targeting AGBL4, researchers can gain insights into the mechanisms underlying tumorigenesis and potentially discover new therapeutic strategies for cancer treatment.With its ability to detect and analyze AGBL4 in various cell types, this antibody is a valuable asset for studies in cell biology, cancer biology, and drug development. By elucidating the functions of AGBL4, researchers can advance their understanding of cellular processes and potentially uncover novel therapeutic targets for cancer and other diseases.
Antibody Name:
AGBL4 Antibody (PACO22298)
Antibody SKU:
PACO22298
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human CBCP6.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HeLa cells, Jurkat cells and A549 cells, using CBCP6 antibody.
Background:
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5 By similarity.
Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes polyglutamates from the carboxy-terminus of target proteins such as MYLK. Mediates deglutamylation of CGAS, regulating the antiviral activity of CGAS. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.
