The AGBL3 Polyclonal Antibody (PAC015344) is a valuable tool for researchers studying AGBL3, a key enzyme involved in protein degradation and cellular homeostasis. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the AGBL3 protein, the antibody enables researchers to detect and analyze its expression in various cell types, making it ideal for studies in cancer biology, neurodegenerative diseases, and cellular stress responses.
AGBL3, also known as ATP/GTP-binding protein-like 3, is essential for maintaining protein quality control and regulating cellular processes such as autophagy and the ubiquitin-proteasome system. Dysregulation of AGBL3 has been linked to cancer progression, neurodegenerative disorders, and metabolic diseases, highlighting its importance as a therapeutic target. By studying the function of AGBL3, researchers can gain valuable insights into disease mechanisms and potential treatment strategies.
Antibody Name:
AGBL3 Antibody (PACO15344)
Antibody SKU:
PACO15344
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human AGBL3
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15344(AGBL3 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Background:
CCP3 (cytosolic carboxypeptidase 3), also known as AGBL3 (ATP/GTP-binding protein-like 3), is a 1,001 amino acid, cytosolic protein that exists as four alternatively spliced isoforms and belongs to the peptidase M14 family. As a metallocarboxypeptidase, CCP3 binds one zinc ion per subunit and may play a role in the processing of tubulin. The gene that encodes CCP3 consists of approximately 161,457 bases and maps to human chromosome 7q33. Housing over 1,000 genes, chromosome 7 comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome.
Synonyms:
ATP/GTP binding protein-like 3
UniProt Protein Function:
AGBL3: Metallocarboxypeptidase that may play a role in the processing of tubulin. Belongs to the peptidase M14 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Protease; EC 3.4.17.-Chromosomal Location of Human Ortholog: 7q33Cellular Component: cytosolMolecular Function: zinc ion binding; metallocarboxypeptidase activityBiological Process: proteolysis
