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Low Endotoxin Purified Anti-Mouse CD272 Antibody [PK18.6] (AGEL2159)

SKU:
AGEL2159
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, κ
Clone:
PK18.6
Conjugation:
None (Low endotoxin)
€229 - €1,219
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD272 Antibody [PK18.6]

The AF-Le Purified Anti-Mouse CD272 Antibody (PK18-6) is a crucial tool for researchers studying the CD272 protein, a cell surface molecule that serves as an immune checkpoint receptor. This antibody, produced through a purification process, shows high specificity and sensitivity in detecting mouse CD272 in various experimental settings. It is particularly useful for applications like flow cytometry and immunohistochemistry, enabling precise and accurate analysis of CD272 expression in immune cells.CD272, also known as BTLA (B- and T-lymphocyte attenuator), plays a pivotal role in regulating immune responses by inhibiting T cell activation and promoting immune tolerance.

Its involvement in immune signaling pathways makes it a promising target for investigating autoimmune diseases, cancer immunotherapy, and infectious diseases. By using the AF-Le Purified Anti-Mouse CD272 Antibody (PK18-6), researchers can gain valuable insights into the function and regulation of CD272, ultimately advancing our understanding of immune system modulation and developing targeted therapies for various immune-related disorders.

Product Title:Low Endotoxin Purified Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL2159
Size:50µg, 500µg, 1mg
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:AF/LE Purified Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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