The Adora2A Polyclonal Antibody (CAB1587) is a vital tool for researchers studying the adenosine receptor A2A (Adora2A), a G protein-coupled receptor involved in a wide range of physiological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications.Adora2A is known for its role in regulating immune responses, inflammation, and neurotransmission. Its dysregulation has been implicated in various conditions, including cancer, cardiovascular diseases, and neurological disorders.
By targeting Adora2A with this specific antibody, researchers can accurately detect and analyze the receptor in different cell types, providing valuable insights into its function and potential therapeutic applications.With its ability to facilitate the study of Adora2A in immunology, oncology, and neuroscience research, the Adora2A Polyclonal Antibody (CAB1587) is a crucial resource for advancing our understanding of this important receptor and its contribution to human health and disease.
Product Name:
ADORA2A Rabbit Polyclonal Antibody
SKU:
CAB1587
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ADORA2A (NP_000666.2).
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding.
Purification Method:
Affinity purification
Gene ID:
135
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of SH-SY5Y cells, using ADORA2A antibody (CAB1587) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
