Adh7 Antibody (PACO36378)
- SKU:
- PACO36378
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Adh7 Antibody (PACO36378)
The ADH7 Polyclonal Antibody (PAC036378) is a valuable tool for researchers studying ADH7, a member of the alcohol dehydrogenase family involved in the metabolism of ethanol and other alcohols in the body. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ADH7 protein, this antibody allows for detection and analysis in a variety of cell types, making it ideal for studies in biochemistry, pharmacology, and toxicology.
ADH7 plays a crucial role in alcohol metabolism, particularly in the liver, where it helps break down ethanol into acetaldehyde. Understanding the function and expression of ADH7 is important for research into alcohol-related diseases, such as alcoholism and liver disease, as well as for assessing the efficiency of alcohol metabolism in individuals. By targeting ADH7, researchers can gain insights into the mechanisms of alcohol metabolism and its impact on human health.
| Antibody Name: | Adh7 Antibody (PACO36378) |
| Antibody SKU: | PACO36378 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Alcohol dehydrogenase class 4 mu/sigma chain protein (1-374AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Mouse liver tissue. All lanes: Adh7 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 40 kDa. Observed band size: 40 kDa. |
| Background: | Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. |
| Synonyms: | Alcohol dehydrogenase class 4 mu/sigma chain (EC 1.1.1.1) (ADH-C2) (Alcohol dehydrogenase 7) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Retinol dehydrogenase), Adh7, Adh-3 Adh3 |
| UniProt Protein Function: | ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Oxidoreductase; Lipid Metabolism - fatty acid; Amino Acid Metabolism - tyrosine; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.1.1.1Cellular Component: cytoplasm; extracellular region; intracellularMolecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; aldehyde oxidase activity; ethanol binding; metal ion binding; NAD binding; oxidoreductase activity; protein homodimerization activity; receptor antagonist activity; retinol binding; retinol dehydrogenase activity; zinc ion bindingBiological Process: ethanol catabolic process; ethanol metabolic process; ethanol oxidation; fatty acid omega-oxidation; response to bacterium; response to ethanol; retinoic acid metabolic process; retinoid metabolic process; retinol metabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q64437 |
| NCBI GenInfo Identifier: | 31560625 |
| NCBI Gene ID: | 11529 |
| NCBI Accession: | NP_033756.2 |
| UniProt Secondary Accession: | Q64437 |
| UniProt Related Accession: | Q64437 |
| Molecular Weight: | 55.9 kDa |
| NCBI Full Name: | alcohol dehydrogenase class 4 mu/sigma chain |
| NCBI Synonym Full Names: | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
| NCBI Official Symbol: | Adh7Â Â |
| NCBI Official Synonym Symbols: | Adh3; Adh4; Adh-3; Adt-1; Adh-3e; Adh-3t; Adh3-e; Adh3-t; AI325182Â Â |
| NCBI Protein Information: | alcohol dehydrogenase class 4 mu/sigma chain |
| UniProt Protein Name: | Alcohol dehydrogenase class 4 mu/sigma chain |
| UniProt Synonym Protein Names: | ADH-C2; Alcohol dehydrogenase 7; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | Adh7Â Â |
| UniProt Entry Name: | ADH7_MOUSE |
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