The ADAT1 Polyclonal Antibody (PACO07605) is a valuable tool for researchers studying ADAT1, a key enzyme involved in RNA editing and tRNA modification processes. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an ideal choice for Western blot applications. By binding specifically to the ADAT1 protein, this antibody enables researchers to detect and analyze ADAT1 expression in a variety of cell types.ADAT1 plays a crucial role in maintaining the accuracy of genetic information by catalyzing the deamination of specific adenosines in RNA molecules.
Dysregulation of ADAT1 activity has been linked to various diseases, including cancer and neurological disorders. By investigating the function of ADAT1, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets.Overall, the ADAT1 Polyclonal Antibody (PACO07605) offers a reliable tool for studying ADAT1 and its role in RNA editing processes. Its high specificity and sensitivity make it a valuable asset for researchers in the fields of molecular biology, genetics, and neurology.
ADAT1: Specifically deaminates adenosine-37 to inosine in tRNA- Ala. Belongs to the ADAT1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: RNA processing; EC 3.5.4.34; HydrolaseChromosomal Location of Human Ortholog: 16q23.1Molecular Function: RNA binding; tRNA-specific adenosine deaminase activityBiological Process: tRNA processing
UniProt Protein Details:
NCBI Summary:
This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
