The ADAMTS4 Polyclonal Antibody (CAB2525) is a valuable tool for researchers studying ADAMTS4, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of enzymes involved in extracellular matrix degradation. This polyclonal antibody, raised in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It specifically targets the ADAMTS4 protein, enabling precise detection and analysis in a variety of cell types.ADAMTS4 plays a crucial role in various physiological processes, including tissue remodeling, inflammation, and cartilage degradation. Dysregulation of ADAMTS4 activity has been implicated in a range of diseases, such as osteoarthritis, rheumatoid arthritis, and cardiovascular disorders.
By studying the functions of ADAMTS4, researchers can gain insights into disease mechanisms and potentially identify new therapeutic targets.This antibody is a valuable tool for investigating the role of ADAMTS4 in disease pathogenesis and progression. Its high specificity and sensitivity make it an ideal choice for researchers conducting studies in molecular biology, biochemistry, and cell biology. By utilizing the ADAMTS4 Polyclonal Antibody, researchers can advance our understanding of ADAMTS4 biology and potentially contribute to the development of novel treatments for ADAMTS4-related diseases.
Product Name:
ADAMTS4 Rabbit Polyclonal Antibody
SKU:
CAB2525
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 74-318 of human ADAMTS4 (NP_005090.3).
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
9507
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart using ADAMTS4 Rabbit pAb(CAB2525) at 1:500 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:3s.
