The ADAMTS2 Polyclonal Antibody (CAB10272) is a valuable tool for researchers studying ADAMTS2, a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family of enzymes that play a crucial role in extracellular matrix remodeling and tissue repair. This polyclonal antibody, generated in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications.ADAMTS2 is known for its role in collagen metabolism, particularly in the processing of procollagens into mature collagen molecules. Dysregulation of ADAMTS2 activity has been implicated in various pathological conditions, including connective tissue disorders and fibrosis.
By targeting ADAMTS2 with this antibody, researchers can gain insights into its expression levels and localization in different cell types and tissues, providing valuable information for studies in tissue homeostasis, wound healing, and fibrotic diseases.With its high specificity and reliability in detecting ADAMTS2, the CAB10272 polyclonal antibody is a valuable tool for advancing research in the fields of extracellular matrix biology, connective tissue disorders, and fibrotic diseases. Its use can help unravel the complexities of ADAMTS2 function and regulation, paving the way for the development of targeted therapies for conditions associated with dysregulated collagen metabolism.
Product Name:
ADAMTS2 Rabbit Polyclonal Antibody
SKU:
CAB10272
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1029-1213 of human ADAMTS2 (O95450).
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method:
Affinity purification
Gene ID:
9509
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAMTS2 Antibody (CAB10272) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
