ADAMTS2 Antibody (PACO18515)
- SKU:
- PACO18515
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ADAMTS2 Antibody (PACO18515)
The ADAMTS2 Polyclonal Antibody (PAC018515) is a vital tool for researchers studying ADAMTS2, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of enzymes that play a role in extracellular matrix biology. This antibody, produced in rabbits, displays strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the ADAMTS2 protein, it allows for the detection and analysis of this enzyme in various cell types, making it an essential component for studies in the fields of biochemistry and molecular biology.ADAMTS2 is known for its involvement in the processing and breakdown of extracellular matrix components such as collagens, affecting processes like tissue development and remodeling.
Dysregulation of ADAMTS2 activity has been linked to various pathological conditions, including connective tissue disorders and fibrotic diseases. By understanding the function and regulation of ADAMTS2, researchers can gain insights into potential therapeutic targets for conditions related to extracellular matrix dysregulation.Overall, the use of the ADAMTS2 Polyclonal Antibody in research can provide valuable information on the role of ADAMTS2 in physiological and pathological processes, offering potential implications for the development of novel therapeutic interventions in conditions involving extracellular matrix remodeling.
| Antibody Name: | ADAMTS2 Antibody (PACO18515) |
| Antibody SKU: | PACO18515 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human ADAMTS2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18515(ADAMTS2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: A431 and 293T cell, Primary antibody: PACO18515(ADAMTS2 Antibody) at dilution 1/200 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18515(ADAMTS2 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. |
| Synonyms: | ADAM metallopeptidase with thrombospondin type 1 motif, 2 |
| UniProt Protein Function: | ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.14; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 5q35.3Cellular Component: extracellular regionMolecular Function: metalloendopeptidase activity; metallopeptidase activityDisease: Ehlers-danlos Syndrome, Type Vii, Autosomal Recessive |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016] |
| UniProt Code: | O95450 |
| NCBI GenInfo Identifier: | 218511944 |
| NCBI Gene ID: | 9509 |
| NCBI Accession: | O95450.2 |
| UniProt Secondary Accession: | O95450 |
| UniProt Related Accession: | O95450 |
| Molecular Weight: | 135 kDa |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 2 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 2 |
| NCBI Official Symbol: | ADAMTS2Â Â |
| NCBI Official Synonym Symbols: | NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3Â Â |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 2 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 2 |
| UniProt Synonym Protein Names: | Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS2Â Â |
| UniProt Entry Name: |
| Antibodies | ELISA Kits |
| ADAMTS2 Antibody (PACO07203) | Human A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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