The ADAMTS17 Polyclonal Antibody (PACO19063) is a valuable tool for researchers studying the ADAMTS17 protein, an enzyme involved in extracellular matrix remodeling and tissue homeostasis. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blotting.ADAMTS17 is known for its role in regulating processes such as cell migration, angiogenesis, and tissue development. Dysregulation of ADAMTS17 has been linked to diseases such as cancer, cardiovascular disorders, and developmental abnormalities.
By targeting ADAMTS17 with this antibody, researchers can explore its functions in different cell types and tissues, providing insights into its potential as a therapeutic target.This antibody is a valuable tool for studies in the fields of biology, biomedicine, and pharmacology, allowing researchers to investigate the role of ADAMTS17 in health and disease. Its high specificity and reactivity make it an essential component for research projects aimed at understanding the complex mechanisms of extracellular matrix modulation and tissue remodeling.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19063(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: PACO19063(ADAMTS17 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19063(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 17
UniProt Protein Function:
ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q24Disease: Weill-marchesani-like Syndrome
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
