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ADAMTS17 Antibody (PACO19063)

SKU:
PACO19063
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ADAMTS17 Antibody PACO19063
  • ADAMTS17 Antibody PACO19063
  • ADAMTS17 Antibody PACO19063
€339
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Description

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ADAMTS17 Antibody (PACO19063)

The ADAMTS17 Polyclonal Antibody (PACO19063) is a valuable tool for researchers studying the ADAMTS17 protein, an enzyme involved in extracellular matrix remodeling and tissue homeostasis. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blotting.ADAMTS17 is known for its role in regulating processes such as cell migration, angiogenesis, and tissue development. Dysregulation of ADAMTS17 has been linked to diseases such as cancer, cardiovascular disorders, and developmental abnormalities.

By targeting ADAMTS17 with this antibody, researchers can explore its functions in different cell types and tissues, providing insights into its potential as a therapeutic target.This antibody is a valuable tool for studies in the fields of biology, biomedicine, and pharmacology, allowing researchers to investigate the role of ADAMTS17 in health and disease. Its high specificity and reactivity make it an essential component for research projects aimed at understanding the complex mechanisms of extracellular matrix modulation and tissue remodeling.

Antibody Name:ADAMTS17 Antibody (PACO19063)
Antibody SKU:PACO19063
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human ADAMTS17
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19063(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageGel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: PACO19063(ADAMTS17 Antibody) at dilution 1/1300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour.
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19063(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.
Synonyms:ADAM metallopeptidase with thrombospondin type 1 motif, 17
UniProt Protein Function:ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q24Disease: Weill-marchesani-like Syndrome
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
UniProt Code:Q8TE56
NCBI GenInfo Identifier:296434401
NCBI Gene ID:170691
NCBI Accession:Q8TE56.2
UniProt Secondary Accession:Q8TE56,Q2I7G4, Q6ZN75
UniProt Related Accession:Q8TE56
Molecular Weight:54,757 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 17
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif 17
NCBI Official Symbol:ADAMTS17  
NCBI Official Synonym Symbols:
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Synonym Protein Names:
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS17  
UniProt Entry Name:ATS17_HUMAN
Antibodies
ADAMTS17 Antibody (PACO03573)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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